Anti-Diabetic Activity of Siddha Formulation Nilavembu Kudineer Chooranam

Abstract

Nilavembu Kudineer (NVK) is one of the well-known classical multi-herbal Siddha formulations useful in the prevention and control of many vector-borne diseases. It is used in siddha medicine to treat malarial fever and related symptoms, as stated in the “Siddha vaithiyathirattu” a Siddha manuscript. An investigation using the aqueous & ethanolic extract of Nilavembu Kudineer chooranam (AENVKC & EENVKC) in diabetes, joint pain, dizziness and other related symptoms.
OBJECTIVES:

The project mainly aims to prepare nilavembu kudineer which is capable of treating diabetes, rich in various phytochemicals. It also involves providing scientifical evidence in proving the analysis. Kudineer chooranam consists of a coarse powder of nine drugs and is used for the preparation of decoction. The prepared drug is subjected to anti-diabetic activity of pancreatic α-amylase & α-glucosidase with acarbose, an amylase inhibitor, the positive control as well as qualitative and quantitative phytochemical screening. Both the ethanolic and aqueous extracts of Nilavembu Kudineer Chooranam were subjected to several phytochemical studies. Carbohydrates, flavonoids, phenols, tannins, saponins, terpenoids, fixed oils, gum and mucilages, and vitamin C are among the many polar secondary metabolites found in the medication. The in-vitro study revealed that the Siddha medicine exhibited an antidiabetic effect in the following sequence, α-glucosidase triumphs over α-amylase. The goal of this study was to give scientific validation of Siddha medications investigated for anti-diabetic efficacy, particularly against different enzymes: α-amylase and α-glucosidase.As a result of these investigations, the potential medicine "Nilavembu Kudineer chooranam" for the treatment of diabetes has been identified. Thus, Nilavembu Kudineer chooranam has been prepared and formulated to replace Acarbose.