Acute and Chronic Anti-Inflammatory activity of Siddha Poly herbal Drug Avuri Karpam

Abstract

Objectives: The aim of the present study was carried out to document the acute and chronic anti inflammatory activity of Avuri Karpam (AK) in wistar albino rats. Methods: Acute anti inflammatory activity study was done using carrageenan induced paw edema method. In this study animals were divided into 5 groups with 6 animals in each group. Group-I (control) received 3% gum acacia 10 ml/kg p.o. Group-II (Carageenan) received 0.1ml of 1% w/v suspension of carrageenan S.C Group-III (standard) received Indomethacin 40 mg/kg p.o. Group-IV received AK 400mg/kg p.o. Group-V received AK 800mg/kg p.o. Chronic anti inflammatory activity were documented by using cotton pellet granuloma method. Totally, four experimental groups and six rats were employed for each experimental group. Group I is control. Group II received Indomethacin 20 mg/kg. Group III received AK 400mg/kg. Group IV received AK 800mg/kg. Results: The results of acute anti inflammatory activity study showed percentage Inhibition at 5 hours of standard drug treated group was 59%. AK 400mg/kg treated group had shown 42% of inhibition. Group V AK 800 mg/kg group showed 54% inhibition which was very close to the standard group inhibition. Chronic anti inflammatory activity result indicated that AK at the dose levels of 400 mg/kg and 800 mg/kg produced a significant decrease the weight of granuloma 46.25.66, 44.4 2.22 respectively when compared with control group and percentage of protection follows in group II 35%, group III 15%, group IV 29.3%.
Conclusion: Since it was concluded that Siddha drug has potent of acute and chronic anti inflammatory activity.